生物活性

• 描述Ertapenem sodium is a β-lactam antibiotic of the carbapenem class that has a broader activity spectrum than most other β-lactam antimicrobials and is more resistant to the enzyme β-lactamase, which is the main mechanism of resistance of many bacteria^[1]. Following an IV bolus of 1 g ertapenem, plasma concentrations declined relatively slowly with a mean ±standard deviation (SD) elimination half-life of 19.3 ±6.6 h^[2]. 1 g of ertapenem administered twice daily, by the iv or sc route, may optimize ertapenem exposure and achievement of PK/PD (pharmacokinetic/pharmacodynamic) targets in patients with BJI(bone and joint infection) ^[3]. Ertapenem has been proven to be clinically and bacteriologically efficacious in randomised controlled trials for the treatment of community acquired infections including complicated intra-abdominal infections, complicated skin and skin-structure infections, acute pelvic infections, complicated urinary tract infections, community-acquired pneumonia and for the prophylaxis of surgical-site infection following elective colorectal surgery. Ertapenem is suited for mild to moderately ill patients with community-acquired infections and for outpatient intravenous antibacterial therapy^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03218397	Gram-negative Bacteremia	Not Applicable	Completed	-	United States, California ... more >> University of California, Los Angeles Los Angeles, California, United States, 90049 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
  NCT03245879	Inappropriate Prescribing ... more >> Antibiotic Stewardship Anti-Bacterial Agents Collapse <<	Not Applicable	Completed	-	-
  NCT02005159	-	-	Completed	-	Spain ... more >> Hospital Universitario de Bellvitge L'Hospitalet de Llobregat, Barcelona, Spain Hospital Son Espases Palma de Mallorca, Mallorca, Spain Hospital Clínic Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Universitario Vall d'Hebron Barcelona, Spain Hospital Universitario Reina Sofía Córdoba, Spain Complejo Hospitalario Universitario A Coruña La Coruña, Spain Hospital San Pedro Logroño, Spain Hospital Universitario La Paz Madrid, Spain Hospital Universitario Ramón y Cajal Madrid, Spain Hospital Marqués de Valdecilla Santander, Spain Hospital Universitario de Valme Sevilla, Spain Hospital Universitario Virgen de la Macarena Sevilla, Spain Hospital Universitario Virgen del Rocío Sevilla, Spain Collapse <<

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• 参考文献

• [1] Pedroso TM, Salgado HR. A Critical Review of Analytical Methods for Determination of Ertapenem Sodium. Crit Rev Anal Chem. 2016;46(1):15‐21

  [2] Hsaiky LM, Salinitri FD, Wong J, et al. Pharmacokinetics and investigation of optimal dose ertapenem in intermittent hemodialysis patients. Nephrol Dial Transplant. 2019;34(10):1766‐1772

  [3] Goutelle S, Valour F, Gagnieu MC, et al. Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection. J Antimicrob Chemother. 2018;73(4):987‐994

  [4] Parakh A, Krishnamurthy S, Bhattacharya M. Ertapenem. Kathmandu Univ Med J (KUMJ). 2009;7(28):454‐460